Everything about sayaph
Everything about sayaph
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We previously determined PS1 mutants Lively inside the absence of NCT [29]. These mutants possessed two missense mutations in PS1: S438P in the ninth transmembrane domain together with one mutation dispersed through the molecule. These PS1 mutations enhanced and modulated the γ-secretase action and lessened the ratio of extended Aβs [32]. We then isolated Aph1 or Pen2 mutants capable to grow inside the absence of NCT. After we experienced screened cells with Pen2 or Aph1 mutations along with the PS1 S438P mutation, we located 13 Aph1 mutants that grew from the absence of NCT (desk 1 and determine one).
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